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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Mol Cancer Ther. 2013 Dec 19;13(2):426–432. doi: 10.1158/1535-7163.MCT-13-0633

Figure 1.

Figure 1

The mixed tumor model composed of EGFR-positive (A431) and EGFR-negative (Balb/DsRed) tumor cells. Pan-IR700 (green) was intravenously injected 1 d before PIT. Scattered Balb/DsRed tumor foci (red) were observed in A431 cells (Green) before PIT. After PIT, severe damage was shown only in EGFR-positive A431 tumors, and the proportion of Balb/DsRed increased with time after PIT. Balb/DsRed cells eventually almost replaced the entire tumor at 7 days after PIT. Histological evaluation before and after PIT. EGFR-targeted PIT induced selective intense necrosis of EGFR-positve A431 cells as indicated by hematoxylin and eosin (H&E) staining. In contrast, spindle shaped Balb/DsRed cells remain intact even after PIT.