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. Author manuscript; available in PMC: 2015 Feb 11.
Published in final edited form as: Circulation. 2013 Nov 14;129(6):660–672. doi: 10.1161/CIRCULATIONAHA.113.005746

Figure 1.

Figure 1

Autosomal dominant polycystic kidney disease (ADPKD) renal epithelia are characterized by abnormal ploidy level and survivin down-regulation. (a) Karyotyping was carried out in freshly isolated epithelial cells from non-ADPKD patients to visualize individual chromosomes (non-cytic kidney). (b) Characterization of individual chromosomes from a single renal epithelium isolated from ADPKD patient indicated tetraploid and abnormal chromosomal composition. (c) Overall karyotype analysis of individual cells confirmed the presence of abnormal genomic compositions (aneuploidy or polyploidy) in cells from ADPKD patients. (d) Kidney tissues from ADPKD patients were also used to confirm survivin expression, and GADPH was used as loading control. Bar graph shows relative survivin expression levels. N=3 each for freshly isolated non-ADPKD and ADPKD kidneys.