Table 3.
Biochemical and hematological parameters of 12 outpatients with COPD, before and after treatment with ESAs and intravenous iron
| Characteristics | Baseline | After treatment | p |
|---|---|---|---|
| Weight kg |
77.2 [69.2–90.5] |
77.9 [70.2–88.1] |
0.32 |
| DBP mmHg |
67.5 [60–88] |
70.1 [66–85] |
0.19 |
| SBP mmHg |
138 [ 120–158] |
134 [121–156] |
0.05 |
| Hb g/dl [11.7–15.5] |
9.9 [9.2–10.6] |
12.4 [11.6–13] |
0.0005 |
| Hct% [35–45] |
29.9 [28–31.5] |
38.1 [35.0–39.4] |
0.0005 |
| MCV fl [80–96] |
89.0[85–92] |
90 [87–92] |
0.17 |
| RBC 106/μl 4.3–5.8 |
3.3 [3.2–3.7] |
3.9 [3.6–4.3] |
0.01 |
| MCH pg [26–34] |
30.5 [29.3–31.7] |
29.8 [29.0–31.6] |
0.99 |
| MCHC g/dl [31–37] |
33.3 [32.6–34.2] |
33.4 [32.9–34.3] |
0.8 |
| RDW% |
14.9 [13.1–16.5] |
15.4 [14.6–16.5] |
0.13 |
| WBC`103/ul [4–11] |
8.0 [4.9–9.2] |
7.1 [6.0–8.3] |
0.38 |
| Lymphocytes% WBC [20–40] |
19.2 [16.1–21.0] |
21.0 [18.0–23.9] |
0.6 |
| Platelets 103/μl [150–450] |
237 [193–303] |
220 [170–282] |
0.51 |
| TSAT% [20–55] |
12.8 [11.0–19.1] |
24.0 [18.5–27.9] |
0.005 |
| Ferritin ng/ml [220–400] |
99 [48.6–127.4] |
330.6 [243.4–615.2] |
0.005 |
| Iron mcg/dl [40–150] |
44,5 [29–61] |
61.5 [57–74] |
0.015 |
| Serum creatinine mg/dl [0.7–1.3] |
2.4 [1.8–3.6] |
2.4 [1.9–3.5] |
0.21 |
| eGFR ml/min/1.73 m2 [ > 90] |
27.5 [19–37] |
28.50 [21–39] |
0.56 |
| GOT U/l [7–40] |
20 [17–39] |
26 [15–41] |
0.04 |
| GPT U/l [5–39] |
16 [11–41] |
21 [10–40] |
0.04 |
| Albumin g/l [35–50] |
38.5 [36–42] |
39.0 [35–41] |
0.36 |
| VAS [0–10] | 2.5 [2–3] | 8.5 [7–10] | 0.0005 |
Values are presented as median with interquartile range [IQR] and reference intervals.
Abbreviations: DBP, diastolic blood pressure; eGFR, estimate glomerular filtration rate; ESAs, erythropoiesis stimulating agents; GOT, alanine amino-transferase; GPT, aspartate amino-transferase; Hb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RBC, red blood cell count; RDW, red cell distribution width; SBP, systolic blood pressure; VAS, Visual Analogue Scale; WBC, white blood cell count; %TSat, % transferrin saturation.