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. 2014 Mar 1;14:29. doi: 10.1186/1471-2261-14-29

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Copyright © 2014 Rodriguez et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Leaflet characterization immediately after collagenase treatment, prior to in vitro organ culture. Quantification of (A) total collagen, (B) HA, (C) total sGAGs, (D) DNA, (E) swelling ratio, and (F) Young’s Modulus indicated that collagenase-treated leaflets were selectively depleted of collagen. (G) Movat’s Pentachrome staining indicated depletion of collagen (yellow) in collagenase-treated leaflets, but retention of other valve components, such as proteoglycans (blue). Scale bar = 400 μm. *P <0.05 compared to undepleted leaflets (no enzyme).