Table 3.
Pre-challenge levels of serum α-casein, β-lactoglobulin and ovalbumin specific IgA, IgG (total) and IgG4 in young children with gastrointestinal symptoms suggestive of non-IgE cow’s milk allergy
| |
DBPCFC negative |
DBPCFC positive |
p-values* |
Controls(with no diet restrictions) |
p-values** |
|---|---|---|---|---|---|
| n = 39 | n = 18 | n = 22 | |||
|
α-casein |
|
|
|
|
|
| Total IgG |
1.16 (0.80–1.70) |
1.36 (0.64–2.88) |
0.8410 |
4.16 (2.01–8.60) |
0.0054* |
| IgG1 |
0.54 (0.30–1.0) |
0.52 (0.25–1.11) |
0.7300 |
0.84 (0.31–2.26) |
0.7761 |
| IgG4 |
0.07 (0.05–0.10) |
0.09 (0.04–0.19) |
0.6394 |
0.21 (0.11–0.37) |
0.0024* |
| Total IgA |
1.46 (1.00–2.13) |
1.33 (0–71–2.50) |
0.4969 |
4.14 (2.20–7.80) |
0.0050* |
|
β-lactoglobulin |
|
|
|
|
|
| Total IgG |
0.43 (0.28–0.70) |
0.27 (0.10–0.71) |
0.3924 |
0.44 (0.27–0.69) |
0.5770 |
| IgG1 |
0.026 (0.009–0.07) |
0.04 (0.01–0.19) |
0.5463 |
0.05 (0.001–0.20) |
0.6848 |
| IgG4 |
0.004 (0.001–0.009) |
0.005 (0.0001–0.03) |
0.9362 |
0.06 (0.01–0.29) |
0.0029* |
| Total IgA |
0.35 (0.24–0.51) |
0.35 (0.20–0.60) |
0.9743 |
0.96 (0.50–1.86) |
0.0100* |
|
Ovalbumin |
|
|
|
|
|
| Total IgG |
2.67 (1.24–5.75) |
3.40 (0.95–12.14) |
0.5857 |
3.27 (0.95–11.27) |
0.8053 |
| IgG1 |
0.58 (0.27–1.25) |
0.95 (0.28–3.24) |
0.4520 |
1.26 (0.40–4.00) |
0.3756 |
| IgG4 |
0.11 (0.05–0.23) |
0.25 (0.07–0.92) |
0.1652 |
0.21 (0.05–0.73) |
0.3299 |
| Total IgA | 1.34 (0.97–1.86) | 0.89 (0.69–1.1) | 0.1147 | 1.82 (0.95–3.48) | 0.1087 |
These levels are expressed as Arbitrary Units (AU). Cow’s milk allergy was diagnosed with the double-blind, placebo-controlled food challenge (DBPCFC). Reported figures are geometric means (with 95% confidence interval of the mean).
*The Mann–Whitney test p-value between the two patient groups.
**p-values calculated by multiple comparison ANOVA (nonparametric Kruskall-Wallis test), comparing the two patient groups and the control group.