Table 1.
Subject demographic data (blood)
DLE+/SLE+ | DLE+/SLE− | Psoriasis | Normal | |
---|---|---|---|---|
N | 28 | 35 | 11 | 32 |
Age at visit, yr (SD) | 45 (13) | 45 (11) | 53 (10) | 43 (11) |
Gender (M/F) | 5/23 | 7/28 | 2/9 | 7/35 |
Ethnicity, No. (%) | ||||
Caucasian | 6 (21%) | 8 (23%) | 8 (73%) | 16 (38%) |
African American | 15 (54%) | 23 (66%) | 0 (0%) | 22 (52%) |
Hispanic | 4 (14%) | 3 (9%) | 2 (18%) | 4 (10%) |
Asian | 3 (11%) | 0 (0%) | 1 (9%) | 0 (0%) |
Other | 0 (0%) | 1 (3%) | 0 (0%) | 0 (0%) |
CLASI activity score, mean (SD) | 9 (9) | 6 (5) | N/A | N/A |
CLASI damage score, mean (SD) | 12 (12) | 8 (5) | N/A | N/A |
SLEDAI score, mean (SD) | 3 (3) | 1 (2) | N/A | N/A |
PASI score, mean (SD) | N/A | N/A | 5 (4) | N/A |
Disease Duration, yr (SD) | 9 (12) | 8 (10) | 10 (11) | N/A |
Lupus medications at study visit, No. (%) | ||||
Topical/Intralesional Corticosteroids | 12 (43%) | 18 (51%) | 3 (27%) | N/A |
Topical Immunomodulators | 2 (7%) | 2 (6%) | 0 (0%) | N/A |
Hydroxychloroquine | 16 (57%) | 18 (51%) | 0 (0%) | N/A |
Chloroquine | 3 (11%) | 3 (9%) | 0 (0%) | N/A |
Quinacrine | 2 (7%) | 4 (11%) | 0 (0%) | N/A |
Methotrexate | 0 (0%) | 2 (6%) | 0 (0%) | N/A |
Prednisone | 9 (32%) | 1 (3%) | 0 (0%) | N/A |
Mycophenolate mofetil | 7 (25%) | 1 (3%) | 0 (0%) | N/A |
Acitretin | 0 (0%) | 0 (0%) | 1 (9%) | N/A |
Ustekinumab | 0 (0%) | 0 (0%) | 1 (9%) | N/A |
None | 0 (0%) | 8 (24%) | 8 (73%) | N/A |
SLE criteria, No. (%)a | ||||
Malar rash | 12 (43%) | 1 (3%) | N/A | N/A |
Discoid rash | 28 (100%) | 35 (100%) | N/A | N/A |
Photosensitivity | 25 (89%) | 24 (69%) | N/A | N/A |
Oral ulcers | 12 (43%) | 5 (14%) | N/A | N/A |
Arthritis | 16 (57%) | 4 (11%) | N/A | N/A |
Serositis | 3 (11%) | 0 (0%) | N/A | N/A |
Renal disorder | 6 (21%) | 0 (0%) | N/A | N/A |
Hematological disorder | 19 (68%) | 4 (11%) | N/A | N/A |
Anti-nuclear antibody | 27 (96%) | 8 (23%) | N/A | N/A |
Immunological disorder | 21 (75%) | 0 (0%) | N/A | N/A |
Mean # of SLE criteria (SD) | 6 (1) | 2 (1) | N/A | N/A |
None of the DLE patients had neurological disorder.
Abbreviations: CLASI = Cutaneous Lupus Disease Activity and Severity Index; DLE = discoid lupus erythematosus; PASI = Psoriasis Activity and Severity Index; SLE = Systemic Lupus Erythematosus; SLEDAI = Systemic Lupus Erythematosus Disease and Activity Index