Skip to main content
. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Pathol. 2014 Mar;232(4):473–481. doi: 10.1002/path.4315

Fig. 1.

Fig. 1

(a) TERT promoter mutations in ovarian clear cell carcinoma. Shown are representative chromatograms of the wild-type TERT promoter and two mutated TERT promoters at two different hot spots. Both mutations create an identical 11bp sequence: CCCCTTCCGGG. (b) An example of ovarian clear cell carcinoma arising from an endometriotic cyst. TERT promoter mutation occurred in clear cell carcinoma but not in the adjacent endometriotic cyst epithelium. (c) Ovarian clear cell carcinoma cell lines with mutated TERT promoter have increased expression of TERT mRNA. Red circles: OV207 and JHOC5 cells with c.−124C>T mutation; blue circle: ES-2 cell with c.[−139C>T;−138C>T] tandem mutation; black horizontal bar: mean; error bar: SEM. (d) Comparison of telomere length between ovarian clear cell carcinomas with and without TERT promoter mutation. Black horizontal bar: mean; error bar: SEM; gray horizontal bar: cutoff for binary analysis.