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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Eur J Immunol. 2013 Nov 15;44(2):450–459. doi: 10.1002/eji.201343477

Figure 5. Activity of SSG based chemotherapy in stat4−/− mice.

Figure 5

Spleen (A) and liver (B) parasite loads in SSG or PBS treated L. donovani infected WT and stat4−/− BALB/c mice. Parasite burdens in spleen of and liver were expressed as mean LDU ±SE. The data were the mean values from four or five individual mice per group at each time point in three independent experiments pooled with similar results. *, P < 0.05, **, P < 0.01 and ***, P < 0.001 using unpaired t test.

Th1 and Th2 cytokine production by splenocytes from SSG or PBS treated L. donovani infected WT and stat4−/− BALB/c mice stimulated with 20μg/ml LdAg. IFN-γ (C), IL-10 (D) and IL-4 (E) were measured by ELISA. Ratios of IFN-γ to IL-10 production (F) are also shown. Data shown were the mean ± SE of triplicates from four or five individual mice per group and are representative of three individual experiments. *, P < 0.05 and **, P < 0.01 using unpaired t test.