Table 1. Distribution of serotypes 6A, 6B, and 6C among Streptococcus pneumoniae isolates recovered from invasive pneumococcal disease (meningitis and bacteremia, n = 12,345) according to age group, from 2002 to 2011.
| Early PCV7 era | Late PCV7 era | PCV13 era | Trend | ||||
| No of Isolates (%) | Age group | 2002–2003 | 2004–2005 | 2006–2007 | 2008–2009 | 2010–2011 | p * |
| All serotypes | All ages | 2581 | 2015 | 2341 | 2833 | 2575 | |
| 0–23 months | 434 | 376 | 398 | 483 | 359 | ||
| 2–15 years | 343 | 425 | 424 | 500 | 455 | ||
| 16–64 years | 892 | 535 | 742 | 970 | 933 | ||
| >64 years | 878 | 444 | 777 | 880 | 828 | ||
| Unknown | 34 | 235 | 0 | 0 | 0 | ||
| Serogroup 6 | All ages | 281 (10.9) | 195 (9.7) | 153 (6.5) | 123 (4.3) | 135 (5.2) | Decrease <10−4 |
| Serotype 6B | All ages | 199 (7.7) | 111 (5.2) | 72 (3.1) | 27 (1.0) | 12 (0.5) | Decrease <10−4 |
| 0–23 months | 71 (16.4) | 33 (8.8) | 12 (3.0) | 6 (1.2) | 1 (0.3) | <10−4 | |
| 2–15 years | 18 (5.2) | 20 (4.7) | 18 (4.2) | 1 (0.2) | 1 (0.2) | <10−4 | |
| 16–64 years | 44 (4.9) | 27 (5.0) | 24 (3.2) | 7 (0.7) | 6 (0.6) | <10−4 | |
| >64 years | 66 (7.5) | 21 (4.7) | 18 (2.3) | 13 (1.5) | 4 (0.5) | <10−4 | |
| Unknown | 0 | 10 | 0 | 0 | 0 | NA | |
| Serotype 6A | All ages | 55 (2.1) | 56 (2.8) | 57 (2.4) | 37 (1.3%) | 32 (1.2) | Decrease <10−3 |
| 0–23 months | 16 (3.7) | 11 (2.9) | 12 (3.1) | 5 (1.0) | 3 (0.8) | <0.05 | |
| 2–15 years | 3 (0.9) | 14 (3.3) | 4 (0.9) | 1 (0.2) | 1 (0.2) | <0.05 | |
| 16–64 years | 15 (1.7) | 11 (2.1) | 19 (2.5) | 15 (1.5) | 15 (1.6) | NS | |
| >64 years | 21 (2.4) | 16 (3.6) | 22 (2.8) | 16 (1.8) | 13 (1.6) | NS | |
| Unknown | 0 | 4 | 0 | 0 | 0 | NA | |
| Serotype 6C | All ages | 16 (0.6) | 16 (0.8) | 22 (0.9) | 59 (2.1) | 91 (3.5) | Increase <10−4 |
| 0–23 months | 1 (0.2) | 0 | 1 (0.3) | 2 (0.4) | 3 (0.8) | NS | |
| 2–15 years | 0 | 2 (0.5) | – (0) | 3 (0.6) | 7 (1.5) | <0.05 | |
| 16–64 years | 10 (1.1) | 6 (1.1) | 11 (1.5) | 26 (2.7) | 43 (4.6) | <10−4 | |
| >64 years | 5 (0.6) | 5 (1.1) | 10 (1.3) | 28 (3.2) | 38 (4.6) | <10−4 | |
| Unknown | 0 | 3 | 0 | 0 | 0 | NA | |
| Serotype 6A/C° | All ages | 11 | 12 | 2 | 0 | 0 | NA |
Introduction of PCV7 in France, March 2002, for children at high risk for IPD; Generalization of PCV7 for children <2 years in 2006; Introduction of PCV13 in France, June 2010.
*Significant trend over the 5 periods, calculation was performed by the extended Mantel-Haenszel Chi square test for linear trend.
°Serotype conventionally determined as 6A that could not be further tested for serotype 6C.
NA, Not applicable; NS, not significant.