Table 5. Antibiotic resistance in carriage and invasive 6B, 6A or 6C pneumococcal isolates over time.
Study year | Serotype | Carriage isolates, No (%) | IPD isolates, No (%) | ||||||||
Total | Non-susceptibility | Total | Non-susceptibility | Resistance patterns* | |||||||
Pen | E | Pen | E | T | Pen-E | E-T | Pen-E-T | ||||
2002–2003 | 6B | 71 | 47 (66.2) | 59 (83.1) | 199 | 108 (54.3) | 171 (85.9) | 85 (42.7) | 60 | 45 | 39 |
6A | 40 | 11 (27.5) | 12 (30.0) | 55 | 18 (32.7) | 28 (50.9) | 7 (12.7) | 13 | 2 | 4 | |
6C | 12 | 7 (58.3) | 7 (58.3) | 16 | 4 (25.0) | 6 (37.5) | 1 (6.3) | 3 | 1 | 0 | |
2004–2005 | 6B | 56 | 38 (66.7) | 48 (85.7) | 111 | 42 (37.8) | 88 (79.3) | 51 (46.0) | 22 | 30 | 19 |
6A | 58 | 14 (24.1) | 16 (27.6) | 56 | 19 (33.9) | 29 (51.8) | 13 (23.2) | 10 | 4 | 8 | |
6C | 22 | 2 (9.1) | 9 (40.9) | 16 | 2 (12.5) | 7 (43.8) | 4 (25.0) | 1 | 4 | 0 | |
2006–2007 | 6B | 21 | 10 (47.6) | 12 (57.2) | 72 | 27 (37.5) | 60 (83.3) | 35 (48.6) | 15 | 22 | 12 |
6A | 46 | 11 (23.9) | 14 (30.4) | 57 | 15 (26.3) | 17 (29.8) | 5 (8.8) | 8 | 0 | 3 | |
6C | 25 | 11 (44.0) | 12 (48.0) | 22 | 10 (45.5) | 16 (72.3) | 10 (45.5) | 4 | 5 | 5 | |
2008–2009 | 6B | 11 | 6 (54.6) | 7 (63.6) | 27 | 11 (40.7) | 21 (77.8) | 12 (44.4) | 6 | 8 | 4 |
6A | 28 | 6 (21.4) | 6 (21.4) | 37 | 11 (29.7) | 14 (37.8) | 4 (10.8) | 7 | 2 | 1 | |
6C | 45 | 17 (37.8) | 26 (57.8) | 59 | 30 (50.9) | 46 (78.0) | 38 (64.4) | 4 | 16 | 22 | |
2010–2011 | 6B | 11 | 6 (54.6) | 5 (45.5) | 12 | 7 (58.3) | 10 (83.3) | 8 (66.7) | 2 | 3 | 4 |
6A | 14 | 7 (50.0) | 7 (50.0) | 32 | 14 (43.8) | 15 (46.9) | 6 (18.8) | 6 | 3 | 2 | |
6C | 88 | 29 (33.0) | 67 (76.1) | 91 | 21 (23.1) | 71 (78.0) | 60 (66.0) | 5 | 44 | 16 |
Pen, penicillin; E, erythromycin; T, tetracycline.
*The main resistance phenotype is indicated in bold.