Table 3.
The risk of association of smoking exposures during pregnancy, combining NQO1 and RAS status, in a case-case analysis Brazil, 2000-2010
| NOQ1 wt /RAS wt n (%) | NOQ1 wt /RAS mut n (%) | OR (95% CI) | NOQ1609CT a /RAS wt n (%) | OR (95% CI) | NOQ1609CT a /RAS mut n (%) | OR (95% CI) | |
|---|---|---|---|---|---|---|---|
|
Mother ever smoked |
|
|
|
|
|
|
|
| No (n,79) |
26 (57.8) |
13 (56.5) |
1b |
29 (74.4) |
1b |
11 (64.7) |
1b |
| Yes (n,45) |
19 (42.2) |
10 (43.5) |
1.05 (0.38-2.90) |
10 (25.6) |
0.47 (0.19-1.20) |
6 (35.3) |
0.75 (0.24-2.38) |
|
Mother smoked 3 months before pregnancy |
|
|
|
|
|
|
|
| No (n,87) |
29 (64.4) |
15 (65.2) |
1b |
30 (76.9) |
1b |
13 (76.5) |
1b |
| Yes (n,37) |
16 (35.6) |
8 (34.8) |
0.97 (0.34-2.77) |
9 (23.1) |
0.54 (0.21-1.42) |
4 (23.5) |
0.56 (0.16-2.00) |
|
Mother smoked during pregnancy |
|
|
|
|
|
|
|
| No (n,98) |
35 (77.8) |
17 (73.9) |
1b |
32 (82.1) |
1b |
14 (82.4) |
1b |
| Yes (n,26) |
10 (22.2) |
6 (26.1) |
1.24 (0.39-3.97) |
7 (17.9) |
0.77 (0.26-2.25) |
3 (17.6) |
0.75 (0.18-3.14) |
|
Someone in the house ever smoked
c
|
|
|
|
|
|
|
|
| No (n,62) |
28 (71.8) |
10 (45.5) |
1b |
18 (46.2) |
1b |
6 (37.5) |
1b |
| Yes (n,54) | 11 (28.2) | 12 (54.5) | 3.06 (1.03-9.07) | 21 (53.8) | 2.97 (1.16-7.60) | 10 (62.5) | 4.24 (1.24-14.50) |
aNQ01 genotype status included allele variants CT and TT. b1 as a reference. cMothers reported the presence of someone smoking at home during the index pregnancy (second-hand smoking). N: number of cases; wt: wild-type; mut: mutation.