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. 2014 Mar 6;9(3):e90848. doi: 10.1371/journal.pone.0090848

Figure 5. DRβ-H induced apoptosis of MCF-7 and MDA-MB-231 cells by activating ERK.

Figure 5

(A) Effect of DRβ-H on the phosphorylation of ERK, P38 and JNK in MCF-7 and MDA-MB-231 cells. (B) U0126 reduced the DRβ-H-induced activation of p-ERK. (C, D) U0126 significantly reduced the DRβ-H–induced apoptosis rate in MCF-7 and MDA-MB-231 cells. (E, F) Early apoptosis rate of cells treated with DRβ-H and/or U0126 of three independent experiments were shown in column statistics. Data are mean±SEM of three independent experiments. *p<0.05, **p<0.01, ***p<0.001 vs. DRβ-H-treated alone group.