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. 2014 Mar 6;9(3):e91303. doi: 10.1371/journal.pone.0091303

Figure 4. Binding of p300/CBP and H3K9ac/H4K5ac to the promoter of BDNF and Cox-2 gene.

Figure 4

The chromatin immunoprecipitation assay was performed with antibodies against p300, CBP, H3K9ac, H4K5ac or non-immune rabbit IgG, after 7 days of treatment with DMSO or curcumin at 20, 40, and 60 mg/kg body weight. Binding of p300/CBP and H3K9ac/H4K5ac to the BDNF promoter (A). Binding of p300/CBP and H3K9ac/H4K5ac to the Cox-2 promoter (B). *p<0.05, CCI versus sham; **p<0.01, CCI versus sham; #p<0.05 curcumin versus vehicle; ##p<0.01 curcumin versus vehicle (n = 10 per group). cur20: curcumin 20 mg/kg; cur40: curcumin 40 mg/kg; cur60: curcumin 60 mg/kg.