Table 1.
Baseline characteristics of 13,881 dialysis patients who underwent renal transplantation between 7/2001 and 6/2006
| Pre-transplant pre-dialysis systolic BP (mmHg) |
<110 | 110– <120 |
120– <130 |
130– <140 |
140– <150 |
150– <160 |
160– <170 |
170– <180 |
>=180 | p for trend |
|---|---|---|---|---|---|---|---|---|---|---|
| N [%] | 3900 [28] | 362 [3] | 798 [6] | 1508 [11] | 2127 [15] | 2144 [15] | 1540 [11] | 832 [6] | 670 [5] | N/A |
| Age (years) | 47 | 47 | 47 | 47 | 48 | 48 | 50 | 50 | 50 | <0.001 |
| Gender (% women) | 42 | 42 | 43 | 40 | 37 | 37 | 36 | 38 | 39 | <0.001 |
| Race (% African-American) | 22 | 20 | 23 | 25 | 28 | 29 | 31 | 29 | 33 | <0.001 |
| Diabetes mellitus (%) | 31 | 26 | 25 | 29 | 32 | 36 | 45 | 52 | 52 | <0.001 |
| BMI (kg/m2) | 26.3 | 26.1 | 26.6 | 26.5 | 26.6 | 26.7 | 26.8 | 27.4 | 27.5 | <0.001 |
| Comorbidities (%): | ||||||||||
| Presence of atherosclerotic heart disease (%) | 8 | 12 | 10 | 8 | 9 | 9 | 9 | 9 | 9 | 0.07 |
| Presence of congestive heart failure (%) | 8 | 8 | 8 | 8 | 11 | 10 | 12 | 14 | 17 | <0.001 |
| Presence of hypertension (%) | 75 | 70 | 72 | 74 | 78 | 79 | 80 | 80 | 82 | <0.001 |
| Presence of cerebrovascular events (%) | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 3 | 2 | 0.30 |
| Presence of peripheral vascular disease (%) | 4 | 4 | 3 | 3 | 4 | 4 | 5 | 4 | 5 | 0.26 |
| Presence of chronic obstructive pulmonary disease (%) | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0.33 |
| Presence of cancer (%) | 2 | 3 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 0.21 |
| Tobacco use (%) | 3 | 4 | 3 | 3 | 3 | 4 | 4 | 4 | 5 | 0.29 |
| Dialysis Vintage (%): | ||||||||||
| 0–6 months | 15 | 15 | 16 | 12 | 10 | 0 | 8 | 11 | 12 | <0.001 |
| 6–24 months | 32 | 29 | 32 | 29 | 28 | 27 | 27 | 23 | 31 | <0.001 |
| 2–5 years | 35 | 33 | 30 | 35 | 37 | 38 | 40 | 40 | 36 | <0.001 |
| >5 years | 18 | 23 | 22 | 24 | 25 | 25 | 25 | 26 | 22 | <0.001 |
| Other variables: | ||||||||||
| Kt/V | 1.53 | 1.58 | 1.59 | 1.6 | 1.59 | 1.57 | 1.56 | 1.53 | 1.53 | <0.001 |
| nPCR (g/kg/day) | 1.02 | 0.97 | 1.01 | 1.02 | 1.03 | 1.03 | 1.03 | 1.03 | 1.02 | <0.001 |
| Laboratory variables: | ||||||||||
| Serum creatinine (mg/dL) | 10.6 | 9.7 | 9.6 | 10.2 | 10.4 | 10.5 | 10.5 | 10.5 | 10.3 | <0.001 |
| Serum albumin (mg/dL) | 3.88 | 3.87 | 3.93 | 3.98 | 3.99 | 3.97 | 3.95 | 3.90 | 3.88 | <0.001 |
| Serum calcium (mg/dL) | 9.4 | 9.3 | 9.4 | 9.4 | 9.4 | 9.4 | 9.4 | 9.4 | 9.3 | 0.18 |
| Blood hemoglobin (g/dL) | 12.0 | 12.0 | 12.3 | 12.2 | 12.2 | 12.2 | 12.1 | 12.0 | 11.9 | <0.001 |
| iPTH (pg/ml) | 452 | 447 | 344 | 417 | 386 | 370 | 420 | 383 | 463 | 0.08 |
| WBC (× 103/l) | 7.1 | 7.0 | 6.8 | 6.9 | 6.9 | 7.0 | 7.0 | 7.2 | 7.3 | <0.001 |
| Number of HLA mismatch | 3.5 | 3.5 | 3.6 | 3.6 | 3.6 | 3.7 | 3.7 | 3.6 | 3.6 | <0.001 |
| PRA (%) | 9 | 13 | 10 | 11 | 11 | 10 | 10 | 11 | 10 | 0.01 |
| PRA >20% (%) | 13 | 19 | 14 | 16 | 16 | 15 | 15 | 15 | 16 | 0.05 |
| Donor age (years) | 38 | 40 | 39 | 39 | 39 | 39 | 40 | 40 | 40 | 0.005 |
| Donor gender (% women) | 47 | 53 | 46 | 48 | 48 | 46 | 48 | 48 | 44 | 0.29 |
| Donor Type (% Living) | 34 | 39 | 38 | 33 | 30 | 32 | 30 | 29 | 33 | <0.001 |
| ECD kidney (%)* | 16 | 15 | 16 | 18 | 20 | 20 | 21 | 21 | 22 | <0.001 |
| Cold Ischemia time (hours)* | 14.0 | 12.7 | 13.7 | 13.6 | 14.6 | 13.9 | 14.6 | 15.3 | 14.0 | 0.002 |
Data are presented as means or percent.
HLA: Human Leucocyte Antibody. PRA: panel reactive antibody (last value prior to transplant). WBC: White Blood Cell count. BMI: Body Mass Index. iPTH: intact parathyroid hormone, EDC: Extended Donor Criteria. nPCR: normalized protein catabolic rate
*
in recipients who received kidney from deceased donors