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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Clin Immunol. 2013 Nov 27;150(2):153–160. doi: 10.1016/j.clim.2013.11.010

Figure 4. IL-10−/− mice exhibit increased IFN-γ and decreased IL-4 expression in the skin following infection.

Figure 4

IL-10−/− and WT mice were VV-infected via skin scarification with 107 PFU. Anti-IL-17 antibody or isotype control was administered retroorbitally, 3 doses of 100 μg per mouse, on days −1, 0, and 2 relative to infection. IL-17 was injected intradermally, one dose of 2.5 μg per mouse, immediately prior to infection. Transcripts encoding IFN-γ and IL-4 in skin RNA were evaluated by quanititative PCR and normalized to the WT infected group, mean ± SEM, (n=3 for IL-10−/−, uninfected mice; n=5–22 for all other groups). * p < 0.05, by unpaired t test, two-tailed.