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(A) Wild-type human ZIC3, RefSeq: NP_003404.1, NM_003413.3. Locations of ZIC3 variants are indicated. cDNA numbering begins at the A (position +1) of the ATG initiation codon (codon 1). ZF = zinc-finger domain. (B) Predicted protein structures and amino acid lengths for wild-type and truncating ZIC3 variants. Arrows represent mutation sites. Hatched bars indicate altered out-of-frame amino acid sequences.
