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. 2014 Mar 6;10(3):e1003920. doi: 10.1371/journal.ppat.1003920

Table 3. Selected examples of most upregulated gene sets after GBS exposure relative to the control group.

Gene set description Gene set length Gene Ontology ID p value
Biological process
myeloid leukocyte differentiation 5 GO:0002573 <0.002
apoptotic DNA fragmentation 25 GO:0006309 <0.002
protein monoubiquitination 17 GO:0006513 <0.002
pinocytosis 5 GO:0006907 <0.002
regulation of cellular pH 5 GO:0030641 <0.002
T cell receptor V(D)J recombination 5 GO:0033153 <0.002
response to laminar fluid shear stress 10 GO:0034616 <0.002
T cell homeostasis 21 GO:0043029 <0.002
regulation of bone resorption 7 GO:0045124 <0.002
positive regulation of erythrocyte differentiation 16 GO:0045648 <0.002
vagina development 10 GO:0060068 <0.002
neural precursor cell proliferation 6 GO:0061351 <0.002
erythrocyte maturation 11 GO:0043249 0.002
positive regulation of survival gene product expression 12 GO:0045885 0.002
positive regulation of macrophage differentiation 8 GO:0045651 0.004
gland development 5 GO:0048732 0.004
Molecular function
Rho GTPase activator activity 24 GO:0005100 0.006
ARF GTPase activator activity 25 GO:0008060 0.006
cytokine binding 20 GO:0019955 0.006
RS domain binding 7 GO:0050733 0.006
telomeric DNA binding 11 GO:0042162 0.007
Rac guanyl-nucleotide exchange factor activity 8 GO:0030676 0.009
eukaryotic cell surface binding 27 GO:0043499 0.009
SH3/SH2 adaptor activity 51 GO:0005070 0.01
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6 GO:0016628 0.01
GTPase activator activity 183 GO:0005096 0.011
organic anion transmembrane transporter activity 15 GO:0008514 0.011
sodium-independent organic anion transmembrane transporter activity 5 GO:0015347 0.011
L-amino acid transmembrane transporter activity 7 GO:0015179 0.013
chromo shadow domain binding 6 GO:0070087 0.013
scavenger receptor activity 45 GO:0005044 0.014
Cellular component
nuclear chromosome 29 GO:0000228 0.006
integral to nuclear inner membrane 5 GO:0005639 0.006
nuclear lamina 9 GO:0005652 0.006
clathrin coated vesicle membrane 13 GO:0030665 0.006
clathrin coat 9 GO:0030118 0.011
T cell receptor complex 12 GO:0042101 0.014
intercellular bridge 6 GO:0045171 0.015
phagocytic vesicle 14 GO:0045335 0.015
extracellular vesicular exosome 7 GO:0070062 0.019
heterogeneous nuclear ribonucleoprotein complex 20 GO:0030530 0.022
IkappaB kinase complex 10 GO:0008385 0.023
spindle midzone 12 GO:0051233 0.024
phosphatidylinositol 3-kinase complex 10 GO:0005942 0.027
chromocenter 8 GO:0010369 0.028
actin filament 44 GO:0005884 0.03