Table 4.

Factors significantly associated with BMD in HCT recipients.

Total BMD Z-score
Risk factor	Comparison	Estimate (SE)	P value
Age at HCT	1 year increase	0.03 (0.016)	0.0354
Gender	Male vs. Female	0.52 (0.167)	0.0024
BMI Percentile	1 % increase	0.01 (0.003)	0.0391
Lean body mass adjusted for height	1 kg increase	0.04 (0.012)	0.0004
IGF-1 SDs	1 unit increase	0.20 (0.100)	0.0472
GHD	Yes vs. No	−0.77 (0.262)	0.0041
Calcium intake (mg/day)	100 mg/day increase	0.06 (0.018)	0.0016
Vitamin D intake (IU/day)	100 IU/day increase	0.16 (0.047)	0.0007
CRT	Yes vs. No	−0.50 (0.205)	0.0160

Lumbar BMD Z-score
Risk factor	Comparison	Estimate (SE)	P value
Gender	Male vs. Female	0.48 (0.191)	0.0134
Lean body mass adjusted for height	1 kg increase	0.03 (0.014)	0.0430
Vitamin D intake (IU/day)	100 IU/day increase	0.13 (0.054)	0.0189

Each of these risk factors was considered separately in an analysis adjusting for Tanner stage, height Z-score, and height Z-score spline at −0.5. Preliminary analyses using a loess smoother showed straight-line relationships between each BMD measure and height Z- score but with a change of the straight line’s slope at height Z-score = −0.5. Thus to adjust for height Z-score, the slope of each outcome on height Z-score was allowed to change at height Z-score = −0.5. GHD, growth hormone deficiency. This table includes only risk factors with P < 0.05, the methods section lists all risk factors considered.