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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Transl Stroke Res. 2013 Nov 19;5(1):38–58. doi: 10.1007/s12975-013-0297-7

Table 1.

Kv channels implicated in neuronal pathology and human neurological disease

Subtype K+ current type Associated pathology Sources
Kv1 Delayed rectifying (Kv1.1–1.3, Kv1.5–1.8), A-type (Kv1.4) Episodic ataxia, epilepsy (Kv1.1, Kv1.2, Kv1.4)

Neuronal apoptosis (Kv1.1, Kv1.3)

Ischemic cell death (Kv1.5)		 7,13,192,196,197,206–257,322,323

150–152

138,139
Kv2 Delayed rectifying Neuronal apoptosis (Kv2.1) 37,46,48,51,52,58, 66,91–96,99–101,106–109,125–137
Kv3 Delayed rectifying (Kv3.1, Kv3.2), A-type (Kv3.3, Kv3.4) Alzheimer’s disease (Kv3.4)

Epilepsy (Kv3.2)		 140,141,146

324
Kv4 A-type Alzheimer’s disease (Kv4.2)

Epilepsy (Kv4.2, Kv4.3)		 147–149

323, 325–330
Kv7 Delayed rectifying, M-type Epilepsy, tinnitus, pain, neuropsychiatric disorders (Kv7.1–7.5) 202,264–317,319