Table 1.
Subtype | K+ current type | Associated pathology | Sources |
---|---|---|---|
Kv1 | Delayed rectifying (Kv1.1–1.3, Kv1.5–1.8), A-type (Kv1.4) | Episodic ataxia, epilepsy (Kv1.1, Kv1.2, Kv1.4) Neuronal apoptosis (Kv1.1, Kv1.3) Ischemic cell death (Kv1.5) |
7,13,192,196,197,206–257,322,323 150–152 138,139 |
Kv2 | Delayed rectifying | Neuronal apoptosis (Kv2.1) | 37,46,48,51,52,58, 66,91–96,99–101,106–109,125–137 |
Kv3 | Delayed rectifying (Kv3.1, Kv3.2), A-type (Kv3.3, Kv3.4) | Alzheimer’s disease (Kv3.4) Epilepsy (Kv3.2) |
140,141,146 324 |
Kv4 | A-type | Alzheimer’s disease (Kv4.2) Epilepsy (Kv4.2, Kv4.3) |
147–149 323, 325–330 |
Kv7 | Delayed rectifying, M-type | Epilepsy, tinnitus, pain, neuropsychiatric disorders (Kv7.1–7.5) | 202,264–317,319 |