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Visual predictive checks (VPCs) by total body weight for overall cohort (A), by post-natal age (PNA) for the overall cohort (B) and by PNA for children (C). Dashed lines represent the 5th and 95th percentiles of the observed data. Solid lines represent the 5th and 95th percentiles of simulated data. Open circles and crosses represent 50th percentile of observed and simulated data. Please note that most adults received daily IV busulfan as per the clinical protocol at the time.
