Table 1.

Summary of Implementation Issues and Potential Solutions

Implementation Issue	Potential Solutions
Low study enrollment	1. Modify emailed recruitment letters and reminders
	a. Increase personalization and visual appeal (e.g., logos, graphics)
	b. Emphasize ease of participation, appreciation for time and effort
	c. Provide individual study timeline and expectations
	d. Revise email schedule regarding number of messages and intervals
	e. Use different email sending addresses for reminder emails to limit effect of spam filters
	2. Streamline study entry to remove potential barriers (real or perceived)
	3. Provide incentive for enrollment
	a. Mail pre-paid monetary incentive
	b. Provide bonus incentive for early enrollment
Low study retention and differential attrition	1. Modify emailed reminders
	a. Emphasize value of survey completion to the trial and appreciation for participants’ contributions
	b. Display timeline to depict individual participant milestones and remaining tasks
	2. Telephone participants who have not completed follow-up
	3. Modify financial incentives
	a. Link incentives to each follow-up survey completed
	b. Increase amount of incentives