Fig. 3.
SF-1/PIP2 and SF-1/PIP3 simulations suggest a solvent accessible headgroup. A) Simulation of mouse SF-1 bound by PIP2 and B) PIP3, based on mouse SF-1/PC structure (3F7D), predicting high solvent accessibility of lipid headgroups, suggesting they may be available to lipid signaling kinases. Coloring scheme same as Fig. 2.