Table 1.
Live enzymalogy and hemocompatibility of nanovectors in mice treated with NP-pArg-siRNA, NP-PEI-siRNA, and PBS as a control.
Test | Units | PBS (mean ± s.d.) | NP-pArg- siRNA (mean ± s.d.) | NP-PEI-siRNA (mean ± s.d.) | Normal (mean range) |
---|---|---|---|---|---|
AST | U/L | 200.0 ± 164.6 | 72.9 ± 11.1 | 2455 ± 222 | 49.6–171.2 |
ALT | U/L | 38.3 ± 12.5 | 43.5 ± 12.0 | 591 ± 88 | 14.1–110.7 |
WBC | × 103/μL | 7.63 ± 2.63 | 4.56 ± 0.58 | 4.57 ± 0.32 | 3.56–10.29 |
Hemolysis | +/−a | − − − | − − − | + + + |
(+/−) indicate number of mice positive (+) or negative (−) for hemolysis.