Table 1.
Candidate genes for IVH from preclinical studies
| Gene | Function of the gene product | Physiologic process |
|---|---|---|
| Activin receptor-like kinase (Alk5) | αvβ8 integrin-mediated TGFβ type I receptor | Angiogenesis |
| Alpha v integrins | Mediate TGFβ activation | Angiogenesis |
| Annexin 7 (anx7) | Vascular Ca++-activated GTPase supporting Ca++ channel activity; Regulates cerebral blood flow | Cerebral blood flow |
| Collagen 4A1 (COL4A1) | Critical component of developing basement membrane | Angiogenesis |
| CREBa-binding protein (CBP) | Transcriptional co-activator required by many transcription factors | Unknown |
| Death receptor 6 (DR6) | Required for VEGF-mediated endothelial sprouting Drives barrier-genesis in the developing brain |
Angiogenesis |
| Friend leukemia integration (Fli) | Member of Ets family of transcription factors Activator of vascular stabilization |
Unknown |
| Inhibitor of differentiation (Id1, Id3) | Interfere with DNA binding of basic helix-loop-helix transcription factors; essential role in angiogenesis | Angiogenesis |
| TGFb β2 receptor (Tgfbr2) | αvβ8 integrin-mediated TGFβ type II receptor | Angiogenesis |
a
CREB – cAMP response binding element;
b
TGF – transforming growth factor