Table 4.
Gene Targets for IVH Consortium Study Subjects
| EUR Gr 2 - 4 IVH | Controls | p value | |
|---|---|---|---|
|
| |||
| Number of subjects | 316 | 389 | |
|
| |||
| Birth weight grams (N, SD) | 821.4 (316, 184.1) | 864.3 (389, 174.0) | <0.0001 |
|
| |||
| GA wks (N, SD) | 25.7 (314, 1.5) | 26.5 (388, 1.5) | <0.0001 |
|
| |||
| Male subjects (%) | 187/316 (59.2%) | 231/389 (59.4%) | 1 |
|
| |||
| IVH status | |||
| Grade 2 | 92 | ||
| Grade 3 | 95 | ||
| Grade 4 | 129 | ||
|
| |||
| Maternal variables | |||
|
| |||
| Maternal prenatal visit (%) | 307/314 (97.8%) | 384/389 (98.7%) | 0.3887 |
|
| |||
| Preeclampsia (%) | 35/314 (11.1%) | 91/388 (23.5%) | <0.0001 |
|
| |||
| Clinical chorioamnionitis (%) | 95/315 (30.2%) | 69/389 (17.7%) | 0.0001 |
|
| |||
| Any ANS w/in 7 d prior to delivery (%) | 277/315 (87.9%) | 336/388 (86.6%) | 0.6504 |
|
| |||
| Complete ANS a within 7 d (%) | 176/316 (55.7%) | 260/389 (66.8%) | 0.003 |
|
| |||
| Multiple gestation (%) | 116/316 (36.7%) | 90/386 (23.3%) | 0.0001 |
|
| |||
| Cesarean section | 187/316 (59.2%) | 281/388 (72.4%) | 0.0002 |
|
| |||
| Delivery room variables | |||
|
| |||
| Apgar 1 minute < 3 (%) | 99/314 (31.5%) | 89/388 (22.9%) | 0.0128 |
|
| |||
| Apgar 5 minutes < 3 (%) | 28/315 (8.9%) | 14/388 (3.6%) | 0.0038 |
|
| |||
| Intubation for resuscitation | 244/295 (82.7%) | 243/351 (69.2%) | <0.0001 |
|
| |||
| Epinephrine for resuscitation | 10/230 (4.3%) | 5/215 (2.3%) | 0.2977 |
|
| |||
| MTHFR polymorphisms | |||
|
| |||
| −1298 CC or CA genotype | 176/316(55.7%) | 176/389(45.2%) | 0.006 |
a
Antenatal steroid exposure