Table 1.

The calculated outer and pore diameters, d_o and d_p, with a description of the pore status, % of β-sheet secondary structure in the pore/C-terminal strands, and “straightness” of the strands by the β-strand order parameter using $S_{\beta }=(1/N_v){\sum }_{k=1}^{N_v}((3{cos}^2{\theta }_{\alpha }-1)/2)$, where θ_α is the angle between the positional vectors connecting two C_α atoms and N_v is the total number of vector pairs for the residues in the pore/C-terminal strands for the Osaka mutant (ΔE22) and wild type Aβ_1–42 barrels.

Aβ barrels	do (nm)	dp (nm)*	Pore status	% of β-sheet pore/C-term	Sβ pore/C-term
Conformer 1 Osaka mutant (ΔE22)	~7.91	~2.10	Opened	41.6/2.4	0.58/0.45
Conformer 2 Osaka mutant (ΔE22)	~7.62	~1.52	Reduced	46.6/5.1	0.57/0.43
Conformer 1 Aβ1–42 (wild type)	~7.87	~1.98	Opened	46.0/3.8	0.56/0.45
Conformer 2 Aβ1–42 (wild type)	~7.97	~2.18	Opened	50.4/5.8	0.57/0.45

^*Pore diameters are averaged along the pore axis within the cutoffs defined by the height of pore.