Table 1. Consensus motifs that define the structure and activity of the GTPase domain of small G-proteins.^a .

Protein	Sequence	G1 (p-loop)	G2 (switch I)	G3 (Switch II)	G4	G5
DBC2	O94844	GDNAVGKT	PTV	DTFGDH	CQLD	TSV
RhoBTB1	Q9BYz6	GDNAVGKT	PTV	DTFGDH	CQLD	TSV
Rac1	P63000	GDGAVGKT	PTV	DTAGQE	TKLD	CSA
Cdc42	P60953	GDGAVGKT	PTV	DTAGQE	TQLD	CSA
RhoA	P61585	GDGACGKT	PTV	DTAGQE	NKKD	CSA
Rap1A	P62834	GSGGVGKS	PTI	DTAGTE	NKCD	SSA
H-Ras	P01112	GAGGVGKS	PTI	DTAGQE	NKCD	TSA
Ran	P62826	GDGGTGKT	ATL	DTAGQE	NKVD	FVA
Rnd1	Q92730	GDVQCGKT	PTV	DTSGSP	CKTD	GSA
Rnd3	P61578	GDSQCGKT	PTV	DTSGSP	CKSD	CSA
RhoU	Q7L0Q8	GDGAVGKT	PTA	DTAGQD	TQSD	CSA
RhoH	Q15669	GDSAVGKT	PTV	DTAGND	TQTD	CSA
Consensus		GXXXXGKT	(P/A)TX	(DXXG)	(N/T)(K/Q)XD	(T/G/C)(V/S)A

^aCompletely conserved residues are in bold, italics.