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. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534

Figure 5. Hyper-responsiveness to paracrine Hh signaling was not observed in IPI-926 treated pancreatic xenografts.

Figure 5

(A) In the MiaPaCa pancreatic xenograft model, 50% tumor growth inhibition was observed with daily oral administration of IPI-926 at 40 mg/kg (N = 12 mice per group). (B) Plasma levels of IPI-926 correlate with the degree and duration of stromal mGli1 inhibition after a single dose of IPI-926 at 40 mg/kg. * indicates a p-value <0.003. Modulation of tumor-derived hGli1 was not observed (data not shown).