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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Arch Biochem Biophys. 2013 Sep 10;0:142–152. doi: 10.1016/j.abb.2013.09.002

Fig. 6.

Fig. 6

CO dehydrogenase (CODH). (A) The reaction catalyzed by CODH. (B) The CODH structure and active site. Dimeric CODH (cartoon view, 3b53, Carboxydothermus hydrogenoformans) contains two [1Ni-4Fe-4S] clusters (green, brown, and yellow spheres) and three [4Fe-4S] clusters (brown and yellow spheres) including one which bridges the subunits. An expanded view of the [1Ni-4Fe-4S] cluster is shown with the ligands shown in stick view. (C) Mechanism of CODH. One proposal for the mechanism of CODH includes a Ni2+-hydride intermediate and retains Ni2+ in all steps; an alternative model invokes a Ni0 state following CO2 release.

(2 column width)