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Size vs exposed amine mediated binding. 50 nm PEG-PEI MSNPs (green, +40 mV) were observed to bind to endothelial cells immediately after injection. 150 nm PEG-NMe3+ MSNP (red, +40 mV) circulated for hours post injection. (a) Merged image, (b) 150 nm PEG-NMe3+, (c) 50nm PEG-PEI. (b and c are same field of view as a)
