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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Circulation. 2013 Nov 7;129(5):598–606. doi: 10.1161/CIRCULATIONAHA.113.002562

Figure 6.

Figure 6

RNase1 treatment of atherosclerosis-prone apoE−/− mice reduces vascular cytokine and adhesion molecule expression. (A-I) ApoE−/− mice fed a high fat diet and treated with vehicle (PBS, filled bars) or RNase1 (open bars) were subjected to wire-induced injury of the common carotid artery. Tnf-α (A), Il-1β (B) and Il-6 (C), Icam-1 (D), Vcam-1 (E), P-selectin (F) and Ccl2 (G) mRNA expression were assessed at indicated time points after injury. Data are expressed as changes in the ratio between target gene expression and Gapdh mRNA. Values represent mean ± SEM (n=12 per group); *p<0.05, **p<0.01, and ***p<0.001 vs. 0h, or as indicated. (H,I) Representative fluorescence images of TNF-α (H) and ICAM-1 (I) protein expression (green) at 1 week after injury, and together with cell nuclei staining (DAPI, blue).