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The process of metastasis. Post-EMT invasive cells leave the primary tumor and enter the circulatory system via trans-endothelial intravasation where the primary tumor cells migrates to a capillary or the lympatic system and then exits the circulation using transendothelial extravasation. At this point, the migrated epithelial cells colonize new tissue and become micrometastases that eventually develop into full blown tumors.
