| Variable | At Basline | Longitudinally | ||||||
|---|---|---|---|---|---|---|---|---|
| Plasma Renin Activity | Plasma Aldosterone | Plasma Renin Activity | Plasma Aldosterone | |||||
| Estimate (95% CI) | P-Value | Estimate (95% CI) | P-Value | Estimate (95% CI) | P-Value | Estimate (95% CI) | P-Value | |
| Recipient Age (years) | 0.004 (−0.12, 0.03) | 0.75 | −0.47 (−2.11, 1.17) | 0.57 | −0.02 (−0.05, 0.01) | 0.25 | −0.25 (−1.47, 0.97) | 0.69 |
| Female Recipient | −0.81 (−1.35, −0.28) | <0.01 | −36.90 (−73.97, 0.16) | 0.05 | −0.65 (−1.39, 0.10) | 0.09 | −25.59 (−52.62, 1.43) | 0.06 |
| Caucasian Recipient | 0.60 (−0.15, 1.35) | 0.12 | 11.15 (−39.95, 62.26) | 0.67 | 0.38 (−0.70, 1.47) | 0.49 | −6.69 (−46.52, 33.15) | 0.74 |
| Recipient BMI (kg/m2) | 0.003 (−0.05, 0.06) | 0.91 | 0.14 (−3.55, 3.83) | 0.94 | 0.03 (−0.04, 0.11) | 0.37 | 3.15 (0.37, 5.93) | 0.03 |
| SBP (mmHg) | −0.005 (−0.024, 0.013) | 0.56 | −0.37 (−.164, 0.90) | 0.57 | 0.006 (−0.02, 0.03) | 0.63 | −0.32 (−1.15, 0.51) | 0.45 |
| DBP (mmHg) | −0.01 (−0.05, 0.02) | 0.44 | −0.51 (−3.05, 2.03) | 0.69 | −0.05 (−0.09, −0.004) | 0.03 | 1.74 (0.27, 3.21) | 0.02 |
| Live donor | −0.48 (−1.10, 0.13) | 0.13 | −43.41 (−86.80, −0.03) | 0.05 | −0.93 (−1.81, −0.05) | 0.04 | −33.3 (−65.35, −1.25) | 0.04 |
| Donor Age (years) | −0.03 (−0.05, −0.01) | 0.01 | 0.01 (−1.53, 1.54) | 0.99 | −0.02 (−0.05, 0.01) | 0.21 | −0.32 (−1.48, 0.85) | 0.59 |
| Female donor | 0.66 (0.14, 1.17) | 0.01 | 15.82 (−20.15, 51.79) | 0.39 | 1.11 (0.36, 1.86) | <0.01 | 16.59 (−10.96, 44.15) | 0.24 |
| Caucasian donor | −0.26 (−0.86, 0.34) | 0.39 | −35.39 (−76.65, 5.87) | 0.09 | 0.44 (−0.44, 1.31) | 0.32 | −10.34 (−42.56, 21.87) | 0.53 |
| Cause of Kidney Disease | ||||||||
| DM | reference | reference | reference | reference | ||||
| HTN | −0.28 (−1.47, 0.90) | 0.64 | −23.08 (−111.87, 65.70) | 0.61 | 1.54 (0.02, 3.05) | 0.05 | −17.96 (−75.43, 39.51) | 0.54 |
| PCKD | −0.12 (−0.96, 0.72) | 0.78 | −3.39 (−63.60, 56.81) | 0.91 | −0.36 (−1.48, 0.77) | 0.53 | 7.74 (−34.11, 49.59) | 0.72 |
| Other | 0.57 (−0.03, 1.17) | 0.06 | 18.50 (−22.98, 59.97) | 0.38 | 0.65 (−0.23, 1.52) | 0.15 | 5.09 (−26.77, 36.94) | 0.75 |
| Smoking | 0.26 (−0.47, 1.00) | 0.48 | 20.89 (−29.17, 70.95) | 0.41 | −0.96 (−1.95, 0.03) | 0.06 | −20.37 (−58.06, 17.31) | 0.29 |
| Hyperlipidemia | −0.24 (−1.88, 1.40) | 0.77 | 117.12 (3.32, 230.92) | 0.04 | −0.62 (−2.34, 1.11) | 0.48 | 46.25 (−20.40, 112.89) | 0.17 |
| Losartan | −0.11 (−0.59, 0.37) | 0.66 | 5.59 (−27.99, 39.17) | 0.74 | 1.61 (0.90, 2.31) | <0.01 | −14.73 (−40.57, 11.11) | 0.26 |
| Thiazides | 0.75 (−0.18, 1.68) | 0.11 | 44.59 (−20.48, 109.66) | 0.18 | −0.003 (−1.29, 1.29) | 0.99 | 24.21 (−23.88, 72.29) | 0.32 |
| Loop diuretics | 0.04 (−0.57, 0.66) | 0.89 | −6.96 (−48.44, 34.52) | 0.74 | 0.17 (−0.68, 1.02) | 0.69 | −25.64 (−56.97, 5.69) | 0.11 |
| Tacrolimus + Rapamycin | 0.13 (−0.89, 1.16) | 0.80 | 7.65 (−65.62, 80.93) | 0.84 | 0.57 (−0.95, 2.09) | 0.46 | 1.98 (−54.92, 58.88) | 0.95 |
| Tacrolimus + MMF | −0.37 (−1.33, 0.60) | 0.45 | 0.65 (−65.87, 67.16) | 0.98 | −0.05 (−1.43, 1.34) | 0.95 | −1.27 (−52.26, 49.73) | 0.96 |
| Tacrolimus + MMF + Pred. | −0.79 (−1.99, 0.40) | 0.19 | 30.04 (−52.28, 112.36) | 0.47 | 0.23 (−1.59, 2.04) | 0.81 | 47.03 (−19.81, 113.86) | 0.17 |
| CSA + MMF | −0.46 (−1.44, 0.53) | 0.36 | 1.13 (−67.19, 69.44) | 0.97 | 0.76 (−0.66, 2.18) | 0.29 | −27.39 (−79.82, 25.04) | 0.30 |
| CSA + MMF + Pred. | −0.74 (−1.79, 0.31) | 0.16 | −22.45 (−94.30, 49.39) | 0.54 | 0.66 (−0.87, 2.18) | 0.40 | −18.64 (−75.46, 38.18) | 0.52 |
- SBP: systolic blood pressure; DBP: diastolic blood pressure; CSA: Cyclosporine, MMF: mycophenolate mofetil, DM: diabetes mellitus, PCKD; polycystic kidney disease, HTN: hypertension, ACR: albumin-creatinine ratio