Variable	Last VvInt/C		Last GFR		Last ACR		VvInt/C Change
	Estimate (95% CI)	P-Value	Estimate (95% CI)	P-Value	Estimate (95% CI)	P-Value	Estimate (95% CI)	P-Value
Plasma Aldosterone	0 (0, 0)	0.47	0.01 (−0.03, 0.06)	0.62	−0.36 (−1.02, 0.3)	0.28	0 (0, 0)	0.61
Plasma Renin Activity	−0.001 (−0.018, 0.017)	0.94	0.84 (−3.32, 4.99)	0.69	18.16 (−47.8, 84.12)	0.58	−0.001 (−0.034, 0.033)	0.96
Recipient Age (years)	−0.001 (−0.003, 0.001)	0.19	−0.07 (−0.46, 0.32)	0.71	1.98 (−4.16, 8.13)	0.52	−0.001 (−0.004, 0.002)	0.41
Female Recipient	0.03 (−0.011, 0.071)	0.15	−4.97 (−14.58, 4.63)	0.30	16.01 (−137.8, 169.81)	0.84	0.022 (−0.054, 0.099)	0.55
Caucasian Recipient	−0.014 (−0.068, 0.04)	0.61	−11.86 (−23.09, −0.64)	0.04	−63.26 (−254.15, 127.64)	0.51	−0.016 (−0.107, 0.076)	0.73
Recipient BMI	0.001 (−0.003, 0.006)	0.56	−0.47 (−1.34, 0.41)	0.29	17.72 (3.09, 32.36)	0.02	0.002 (−0.006, 0.01)	0.55
SBP (mmHg)	0 (−0.001, 0.002)	0.65	−0.11 (−0.41, 0.19)	0.47	2.22 (−2.83, 7.27)	0.38	0 (−0.003, 0.003)	1.00
DBP (mmHg)	0 (−0.003, 0.003)	0.95	0.36 (−0.24, 0.97)	0.23	−5.96 (−15.96, 4.04)	0.24	−0.002 (−0.006, 0.003)	0.53
Hypertension	0.01 (−0.028, 0.049)	0.60	0.53 (−8.02, 9.09)	0.90	24.01 (−114.56, 162.59)	0.73	0.043 (−0.022, 0.107)	0.19
Acute Rejection	0.033 (−0.019, 0.085)	0.20	−8.12 (−20.49, 4.25)	0.19	147.27 (−59.74, 354.28)	0.16	0.085 (−0.006, 0.175)	0.06
<3 HLA Matches	0.018 (−0.018, 0.054)	0.33	−7.74 (−15.68, 0.19)	0.06	62.23 (−66.96, 191.43)	0.34	−0.004 (−0.064, 0.055)	0.89
Live Donor	−0.01 (−0.057, 0.036)	0.65	−3.14 (−13.56, 7.28)	0.55	−79.6 (−247.76, 88.57)	0.35	0.011 (−0.061, 0.083)	0.76
Donor Age (years)	0 (−0.001, 0.002)	0.61	−0.03 (−0.45, 0.39)	0.87	0.02 (−6.39, 6.44)	0.99	−0.001 (−0.003, 0.002)	0.70
Female Donor	−0.006 (−0.045, 0.034)	0.77	−4.29 (−12.88, 4.3)	0.32	−2.03 (−146.53, 142.46)	0.98	−0.006 (−0.071, 0.059)	0.85
Caucasian Donor	0.044 (−0.004, 0.092)	0.07	6.59 (−4.72, 17.89)	0.25	103.56 (−78.51, 285.63)	0.26	0.067 (−0.019, 0.153)	0.12
Cause of Kidney Disease
DM	reference		reference		reference		reference
HTN	−0.051 (−0.126, 0.024)	0.18	7.66 (−8.42, 23.73)	0.34	−107.73 (−382.49, 167.04)	0.43	−0.052 (−0.173, 0.069)	0.38
PCKD	−0.001 (−0.061, 0.059)	0.97	2.03 (−10.54, 14.6)	0.75	100.06 (−114.75, 314.87)	0.35	0.053 (−0.052, 0.159)	0.31
Other	−0.03 (−0.082, 0.022)	0.25	8.25 (−3.08, 19.58)	0.15	16.01 (−169.33, 201.35)	0.86	−0.039 (−0.127, 0.049)	0.37
Losartan	−0.01 (−0.047, 0.027)	0.60	−6.78 (−14.95, 1.39)	0.10	96.32 (−39.7, 232.33)	0.16	−0.05 (−0.114, 0.013)	0.11
Thiazides	−0.016 (−0.085, 0.052)	0.63	7.15 (−7.38, 21.67)	0.33	−77.25 (−326.01, 171.51)	0.54	−0.048 (−0.181, 0.086)	0.47
Loop Diuretics	0 (−0.051, 0.051)	0.99	2.9 (−7.14, 12.93)	0.56	66.74 (−107.71, 241.2)	0.45	−0.016 (−0.098, 0.066)	0.69
Tacrolimus + Rapamycin	0.067 (−0.014, 0.148)	0.10	−16.2 (−34.78, 2.37)	0.09	−137.41 (−445.59, 170.78)	0.37	0.049 (−0.072, 0.171)	0.41
Tacrolimus + MMF	0.02 (−0.061, 0.101)	0.62	3.37 (−15.05, 21.78)	0.71	−322.12 (−612.94, −31.31)	0.03	−0.003 (−0.147, 0.14)	0.96
Tacrolimus+ MMF + Pred.	−0.001 (−0.112, 0.111)	0.99	−6.91 (−30.12, 16.3)	0.55	−362.28 (−750.67, 26.1)	0.07	−0.127 (−0.343, 0.088)	0.24
CSA + MMF	0.01 (−0.076, 0.096)	0.82	−5.42 (−24.32, 13.48)	0.57	−334.44 (−635.84, −33.04)	0.03	−0.088 (−0.224, 0.049)	0.20
CSA + MMF + Pred.	0.009 (−0.081, 0.099)	0.85	3.62 (−15.74, 22.98)	0.71	−401.41 (−715.09, −87.73)	0.01	−0.04 (−0.186, 0.106)	0.58

SBP: systolic blood pressure; DBP: diastolic blood pressure; CSA: Cyclosporine, MMF: mycophenolate mofetil, DM: diabetes mellitus, PCKD: polycystic kidney disease, HTN: hypertension, ACR: albumin creatinine ratio