| Variable | VvInt/C doubling or ESRD from IF/TA | VvInt/C doubling or any ESRD | Cr Doubling, ESRD or Death | |||
|---|---|---|---|---|---|---|
|
| ||||||
| OR (95% CI) | P-Value | OR (95% CI) | P-Value | OR (95% CI) | P-Value | |
| Plasma Aldosterone | 1.01 (1, 1.01) | 0.21 | 1.01 (1, 1.02) | 0.08 | 1 (0.99, 1) | 0.39 |
| Plasma Renin Activity | 0.91 (0.49, 1.7) | 0.77 | 0.47 (0.17, 1.27) | 0.14 | 0.92 (0.57, 1.47) | 0.73 |
| Recipient Age (years) | 1 (0.93, 1.07) | 0.90 | 1 (0.92, 1.08) | 0.96 | 1.02 (0.97, 1.07) | 0.46 |
| Female Recipient | 0.36 (0.12, 1.08) | 0.07 | 0.37 (0.12, 1.08) | 0.07 | 0.93 (0.51, 1.69) | 0.80 |
| Caucasian Recipient | 0.9 (0.29, 2.75) | 0.85 | 0.43 (0.11, 1.69) | 0.23 | 1.86 (0.81, 4.27) | 0.14 |
| Recipient BMI | 1.07 (0.89, 1.28) | 0.46 | 1.1 (0.89, 1.37) | 0.38 | 1.07 (0.95, 1.22) | 0.27 |
| SBP (mmHg) | 0.95 (0.88, 1.02) | 0.16 | 1.02 (0.96, 1.08) | 0.57 | 1.04 (1, 1.09) | 0.05 |
| DBP (mmHg) | 1.03 (0.91, 1.17) | 0.65 | 0.85 (0.73, 1) | 0.05 | 0.96 (0.88, 1.04) | 0.33 |
| Hypertension | NA* | 11.99 (1.9, 75.59) | 0.01 | 2.07 (1.03, 4.18) | 0.04 | |
| Acute Rejection | 4.62 (1.8, 11.83) | <0.01 | 8.14 (2.04, 32.38) | <0.01 | 2.66 (1.36, 5.18) | <0.01 |
| <3 HLA Matches | 3.13 (1.08, 9.11) | 0.04 | 6.17 (1.37, 27.74) | 0.02 | 1.66 (0.9, 3.04) | 0.10 |
| Live Donor | 0.43 (0.13, 1.39) | 0.16 | 0.69 (0.22, 2.15) | 0.52 | 0.71 (0.36, 1.4) | 0.32 |
| Donor Age (years) | 1.02 (0.95, 1.1) | 0.55 | 0.96 (0.86, 1.07) | 0.48 | 1 (0.95, 1.06) | 0.92 |
| Female Donor | 1.01 (0.41, 2.49) | 0.98 | 0.68 (0.18, 2.48) | 0.56 | 1.56 (0.85, 2.86) | 0.15 |
| Caucasian Donor | 1.29 (0.52, 3.16) | 0.59 | 1.12 (0.37, 3.35) | 0.84 | 0.37 (0.19, 0.73) | <0.01 |
| Cause of Kidney Disease | ||||||
| DM | reference | reference | reference | |||
| HTN | 1.31 (0.13, 13.37) | 0.82 | 0.25 (0, 42.24) | 0.59 | 3.38 (0.59, 19.23) | 0.17 |
| PCKD | 0.93 (0.1, 8.29) | 0.95 | 2.65 (0.08, 83.56) | 0.58 | 0.51 (0.11, 2.36) | 0.39 |
| Other | 0.84 (0.18, 3.92) | 0.83 | 3.53 (0.33, 37.52) | 0.30 | 0.57 (0.18, 1.77) | 0.33 |
| Losartan | 0.62 (0.28, 1.37) | 0.24 | 0.24 (0.08, 0.76) | 0.02 | 0.5 (0.27, 0.91) | 0.02 |
| Thiazides | 0.75 (0.17, 3.23) | 0.70 | 0.79 (0.16, 3.96) | 0.77 | 0.75 (0.26, 2.16) | 0.59 |
| Loop Diuretics | 1.09 (0.41, 2.86) | 0.87 | 3.64 (0.96, 13.77) | 0.06 | 1.03 (0.55, 1.93) | 0.92 |
| Tacrolimus+ Rapamycin | 3.32 (0.98, 11.27) | 0.05 | 0.87 (0.18, 4.24) | 0.86 | 1.64 (0.52, 5.14) | 0.40 |
| Tacrolimus + MMF | 1.59 (0.57, 4.44) | 0.38 | 0.36 (0.07, 1.89) | 0.23 | 1.55 (0.53, 4.53) | 0.42 |
| Tacrolimus + MMF + Pred. | 2.62 (0.66, 10.33) | 0.17 | 0.68 (0.1, 4.54) | 0.69 | 1.41 (0.38, 5.25) | 0.60 |
| CSA + MMF | NA* | 0.06 (0.01, 0.59) | 0.02 | 0.58 (0.16, 2.09) | 0.41 | |
| CSA + MMF + Pred. | NA* | 0.13 (0.02, 1.06) | 0.06 | 1.11 (0.31, 3.96) | 0.88 | |
| Iothalamate GFR | 1 (0.95, 1.05) | 0.95 | 0.97 (0.91, 1.03) | 0.32 | 1.04 (1.01, 1.08) | 0.02 |
*
excluded due to collinearity
SBP: systolic blood pressure; DBP: diastolic blood pressure; CSA: Cyclosporine, MMF: mycophenolate mofetil, DM: diabetes mellitus, PCKD: polycystic kidney disease, HTN: hypertension, ACR: albumin-creatinine ratio