Table 2.
Predictors of Plasma Renin Activity (ng/ml/h) and Plasma Aldosterone (pg/ml)
| VvInt/C doubling or ESRD from IF/TA | ||
|---|---|---|
| Variable | OR (95% CI) | P-Value |
| Plasma Aldosterone | 1.01 (1, 1.01) | 0.21 |
| Plasma Renin Activity | 0.91 (0.49, 1.7) | 0.77 |
| Female Recipient | 0.36 (0.12, 1.08) | 0.07 |
| Acute Rejection | 4.62 (1.8, 11.83) | <0.01 |
| <3 HLA Matches | 3.13 (1.08, 9.11) | 0.04 |
| Tacrolimus+ Rapamycin | 3.32 (0.98, 11.27) | 0.05 |
| VvInt/C doubling or any ESRD | ||
| Plasma Aldosterone | 1.01 (1, 1.02) | 0.08 |
| Plasma Renin Activity | 0.47 (0.17, 1.27) | 0.14 |
| Female Recipient | 0.37 (0.12, 1.08) | 0.07 |
| DBP (mmHg) | 0.85 (0.73, 1) | 0.05 |
| Hypertension | 11.99 (1.9, 75.59) | 0.01 |
| Acute Rejection | 8.14 (2.04, 32.38) | <0.01 |
| <3 HLA Matches | 6.17 (1.37, 27.74) | 0.02 |
| Losartan | 0.24 (0.08, 0.76) | 0.02 |
| Loop Diuretics | 3.64 (0.96, 13.77) | 0.06 |
| CSA + MMF | 0.06 (0.01, 0.59) | 0.02 |
| CSA + MMF + Pred. | 0.13 (0.02, 1.06) | 0.06 |
| Creatinine doubling, ESRD or Death | ||
| Plasma Aldosterone | 1 (0.99, 1) | 0.39 |
| Plasma Renin Activity | 0.92 (0.57, 1.47) | 0.73 |
| SBP (mmHg) | 1.04 (1, 1.09) | 0.05 |
| Hypertensive | 2.07 (1.03, 4.18) | 0.04 |
| Acute Rejection | 2.66 (1.36, 5.18) | <0.01 |
| <3 HLA Matches | 1.66 (0.9, 3.04) | 0.10 |
| Caucasian Donor | 0.37 (0.19, 0.73) | <0.01 |
| Losartan | 0.5 (0.27, 0.91) | 0.02 |
| Iothalamate GFR | 1.04 (1.01, 1.08) | 0.02 |
SBP: systolic blood pressure; DBP: diastolic blood pressure; CSA: Cyclosporine, MMF: mycophenolate mofetil, DM: diabetes mellitus, PCKD; polycystic kidney disease, HTN: hypertension, ACR: albumin-creatinine ratio