Table 1.

Treated patients

	Age	Protein	ANC	ISS	β2	Priors	FISH	Karyotype
1. 30 mg/m2 bolus / 30 mg/m2 CIV
Patient E	58	IgG-L	1900	2	3	3	Unsuccessful	Normal
Patient F	58	IgG-K	3300	3	9.3	9	Trisomies/Tetrasomies, 13q−	Complex
Patient O	60	IgG-L	2200	2	1.4	9	Unsuccessful	Normal
Patient J	78	IgG-L	1300	3	7.7	6	Trisomies/Tetrasomies, 13−	Complex
Patient D	49	IgG-L	1900	3	6.7	3	Tetrasomies, 13−, 17p−	Complex
2. 30 mg/m2 bolus / 50 mg/m2 CIV
Patient B	49	IgG-K	1200	3	6.9	9	13q−, t(11;14)	Complex
Patient G	65	IgG-K	3300	3	6.9	10	Unsuccessful	Complex
Patient C	69	IgG-K	1700	3	6.2	6	Trisomies, 13−	Failed
3. 50 mg/m2 bolus / 50 mg/m2 CIV
Patient Q	60	IgG-K	2300	1	2.9	4	Trisomies/Tetrasomies, 17p−, 13q−, 12p−	Complex
Patient K	52	IgA-L	1900	1	2.5	11	Trisomies, 1q21+, 1q23−,	Complex
Patient P	81	LLC	1600	2	2.7	5	Trisomies/Tetrasomies, 1q+	Failed
Patient M	66	IgA-L	1200	3	6.3	12	Tetraploid, 13q−, 1q+	Failed
Patient A	64	IgG-K	5900	1	2	6	Trisomies, 1p−, 13q−	Complex
Patient H	72	IgA-K	2100	1	1.7	3	Tetraploid, 13−, t(4;14)	Complex
Patient R	64	IgG-K	4300	3	6.8	9	Unsuccessful	Complex

Patients F, O, and P were replaced as they did not complete the first cycle due to progression or toxicity. Patient E was the only patient that did not have CD138-selected FISH. Patients with 13q deletion showed one copy of 13q14.3 (D13S319) while those with 13- deletion had only one copy of the LAMP probe. Abbreviations Protein is the paraprotein secreted with lambda light chains represented as LLC. International Staging System (ISS) and β2-microglobulin represent values obtained during screening. Priors are the number of prior treatments received, not lines of therapy. Karyotype was listed as failed when there were insufficient metaphases.