Table 3. Univariate and multivariate analysis for overall survival after surgery using cox RR relative risk.

Variables	Univariate analysis		Multivariate analysis
	HR(95%CI)	P value	HR(95%CI)	P value
LDH-A expression
Positive/Negative	1.853 (1.404–2.444)	<0.001	1.829 (1.375–2.433)	<0.001
Age
<60/≥60	1.446 (1.030–2.032)	0.033	1.431(0.995–2.058)	0.053
Tumor size
<4/≥4 cm	2.297 (1.505–3.504)	<0.001	1.429 (0.921–2.217)	0.111
Depth of invasion
Tis-1/T2–4	5.114(1.889–13.843)	0.001	1.414(0.389–5.137)	0.598
Lauren grade
Intestinal/Diffuse	1.978 (1.396–2.803)	<0.001	2.142 (1.350–3.399)	0.001
TNM Stage
0–I/II–IV	8.235 (3.042–22.30)	<0.001	1.410(1.105–1.799)	0.006
Lymph node metastasis
Positive/Negative	3.146 (1.989–4.977)	<0.001	1.571 (0.934–2.644)	0.089
Lymphatic invasion
Positive/Negative	2.041 (1.424–2.924)	<0.001	1.467 (1.006–2.139)	0.046
Histological type
Differentiated/Undifferentiated	1.460 (1.033–2.063)	0.032	0.902 (0.579–1.404)	0.674