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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Trends Endocrinol Metab. 2013 Oct 30;25(2):53–59. doi: 10.1016/j.tem.2013.10.001

Figure 2. Schematic of putative actions of bioactive lipids.

Figure 2

(A) The putative actions of bioactive lipids on bone growth, as shown. These include generation of oxidant stress and inhibition of osteoblastic differentiation that leads to decreased bone formation, and promotion of osteoclastic differentiation which in turn leads to increased bone resorption, ultimately resulting in bone loss. (B) Bioactive lipids may also affect the anabolic effects of intermittent parathyroid hormone treatment [PTH(1–34), teriparatide], including generation of bioactive lipids, which may be blocked by apolipoprotein peptide mimetics and/ or antioxidant enzymes.