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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Mol Med (Berl). 2013 Nov 20;92(2):151–164. doi: 10.1007/s00109-013-1102-5

Fig. 1.

Fig. 1

Ganetespib treatment inhibits accumulation of HIF-1α in MDA-MB-231 and MDA-MB-435 cells exposed to hypoxia. Cells were pretreated with ganetespib (100 nM) or vehicle for 30 min and exposed to 20% or 1% O2 for 6 h. Whole cell lysates were prepared and aliquots were subjected to immunoblot assay using antibodies against HIF-1α, HIF-2α, HIF-1β, or actin.