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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Mol Med (Berl). 2013 Nov 20;92(2):151–164. doi: 10.1007/s00109-013-1102-5

Fig. 3.

Fig. 3

Ganetespib treatment inhibits local tissue invasion. a Sections from the invasive front of primary tumors from mice treated with Veh or Gan were analyzed by immunohistochemistry for HIF-1α expression. Arrows indicate the direction of invasion in Veh section and dotted line indicates the well-defined border between tumor (T) and stromal tissue (S) in Gan section. b The percentage of cells that were stained for HIF-1α is shown; **p < 0.01 vs vehicle, Student’s t test (mean ± SEM). c-f Adjacent sections from the tumor interior containing areas of necrosis (N) were analyzed by immunohistochemistry for expression of HIF-1α (c) or P4HA1 (e). Right: The percentage of cells in the section that were stained for HIF-1α (d) or P4HA1 (f) is shown; **p < 0.01, ***p < 0.001 vs vehicle, Student’s t test (mean ± SEM).