Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cell cycle-dependent mutual exclusion of BRCA1 and Rif1 from DSBs. In G1, Rif1 prevents the accumulation of BRCA1 at DSBs and acts downstream of 53BP1 to block resection, thereby promoting c-NHEJ. In S/G2, phosphorylated CtIP blocks Rif1 from binding to 53BP1, thereby allowing resection and promoting HDR. CtIP also plays a role in promoting resection but this attribute appears to be independent of its binding to BRCA1.
