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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: J Am Coll Cardiol. 2013 Oct 16;63(4):358–368. doi: 10.1016/j.jacc.2013.09.025

Figure 1. Human CYB561 genomics, common 3’-UTR variant A+1485G (rs3087776), and micro-RNA hsa-miR-1294.

Figure 1

Figure 1

Figure 1

1A. Location on chromosome 17q23, with exon/intron structure and position of 3’-UTR variant.

1B. Local alignment across primate species. The local sequence is evolutionally conserved across most primates, while the ancestral allele (based upon chimpanzee and other primate sequences) seems to be the A-allele.

1C. Alignment of the A+1485G region with the micro-RNA hsa-miR-1294 motif. The A-allele provides a superior match.