Table 2. Effects of CYB561 3'-UTR variant G+1485A on basal/resting heart rate in multiple independent groups: Meta-analysis.

Effect sizes (beta, SE) were determined by regression (SPSS) in each of the three contributory groups, with meta-analysis in STATA.

Group	Alleles, Minor/Major	Minor allele frequency	N	Trait	Model	Beta (slope per allele)	SE (of beta)	P-value
Twins/sibs	A/G	0.475	576	Heart rate	Additive	−1.636	0.627	0.009265
Kaiser-1	A/G	0.454	926	Heart rate	Additive	−0.412	0.544	0.449
Kaiser-2	A/G	0.486	1077	Heart rate	Additive	−1.30	0.863	0.136
Meta-result	A/G	-	2579	Heart rate	Additive	−0.899	0.327	0.007

Groups: Kaiser-1, Kaiser-2: Independent samples (−1,−2) from a large white primary care

Bold: meta-result. Analyses in twins were adjusted for age and sex (as well as ancestry), while results in the Kaiser subjects were adjusted for age and sex.