Table 2. Distribution frequency of vascular endothelial growth factor (VEGF)-C genotypes in 520 controls and 233 patients with urothelial cell carcinoma (UCC).

Variable	Controls (N = 520) n (%)	Patients (N = 233) n (%)	OR (95% CI)	AOR (95% CI)
rs3775194
GG	372 (71.5%)	175 (75.1%)	1.00	1.00
GC	137 (26.4%)	56 (24.0%)	0.869 (0.607∼1.244)	0.862 (0.546∼1.360)
CC	11 (2.1%)	2 (0.9%)	0.386 (0.085∼1.762)	0.329 (0.060∼1.801)
GC+CC	148 (28.5%)	58 (24.9%)	0.833 (0.585∼1.185)	0.811 (0.519∼1.265)
rs11947611
AA	221 (42.5%)	93 (39.9%)	1.00	1.00
AG	249 (47.9%)	114 (48.9%)	1.088 (0.783∼1.511)	0.841 (0.559∼1.265)
GG	50 (9.6%)	26 (11.2%)	1.236 (0.726∼2.104)	1.538 (0.780∼3.031)
AG+GG	299 (57.5%)	140 (60.1%)	1.113 (0.812∼1.524)	0.929 (0.628∼1.374)
rs1485766
CC	190 (36.5%)	63 (27.0%)	1.00	1.00
CA	239 (46.0%)	115 (49.4%)	1.451 (1.011∼2.083) *	1.494 (1.051∼2.345) *
AA	91 (17.5%)	55 (23.6%)	1.823 (1.174∼2.829) *	2.494 (1.423∼4.373) *
CA+AA	330 (63.5%)	170 (73.0%)	1.554 (1.106∼2.182) *	1.742 (1.143∼2.654) *
rs7664413
CC	309 (59.4%)	132 (56.7%)	1.00	1.00
CT	188 (36.2%)	89 (38.2%)	1.108 (0.801∼1.533)	1.282 (0.847–1.939)
TT	23 (4.4%)	12 (5.1%)	1.221 (0.590∼2.527)	1.146 (0.423–3.103)
CT+TT	211 (40.6%)	101 (43.3%)	1.121 (0.820∼1.532)	1.267 (0.849–1.889)
rs2046463
AA	309 (59.4%)	132 (56.7%)	1.00	1.00
AG	188 (36.2%)	89 (38.2%)	1.108 (0.801∼1.533)	1.282 (0.847∼1.939)
GG	23 (4.4%)	12 (5.1%)	1.221 (0.590∼2.527)	1.146 (0.423∼3.103)
AG+GG	211 (40.6%)	101 (43.3%)	1.121 (0.820∼1.532)	1.267 (0.849∼1.889)

Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated by logistic regression models. Adjusted ORs (AORs) and their 95% CIs were estimated by multiple logistic regression models after controlling for age, gender, and tobacco consumption.

*p<0.05, statistically significant.