Table 3. Distribution frequency of vascular endothelial growth factor (VEGF)-C genotypes in 310 controls and 166 patients with urothelial cell carcinoma (UCC) without tobacco consumption.

Variable	Controls (N = 310) n (%)	Patients (N = 166) n (%)	OR (95% CI)	AOR (95% CI)
	Among non-tobacco consumers (n = 476)
rs3775194
GG	232 (74.8%)	126 (75.9%)	1.00	1.00
GC	69 (22.3%)	38 (22.9%)	1.014 (0.646∼1.593)	0.859 (0.488∼1.514)
CC	9 (2.9%)	2 (1.2%)	0.409 (0.087∼1.923)	0.411 (0.071∼2.390)
GC+CC	78 (25.2%)	40 (24.1%)	0.944 (0.609∼1.464)	0.810 (0.467∼1.406)
rs11947611
AA	128 (41.3%)	68 (41.0%)	1.00	1.00
AG	152 (49.0%)	82 (49.4%)	1.015 (0.682∼1.512)	0.729 (0.438∼1.211)
GG	30 (9.7%)	16 (9.6%)	1.004 (0.512∼1.970)	1.469 (0.625∼3.453)
AG+GG	182 (58.7%)	98 (59.0%)	1.014 (0.691∼1.487)	0.824 (0.509∼1.335)
rs1485766
CC	124 (40.0%)	42 (25.3%)	1.00	1.00
CA	134 (43.2%)	87 (52.4%)	1.917 (1.232∼2.982) *	1.983 (1.320∼2.802) *
AA	52 (16.8%)	37 (22.3%)	2.101 (1.215∼3.633) *	2.486 (1.251∼4.938) *
CA+AA	186 (60.0%)	124 (74.7%)	1.968 (1.297∼2.987) *	1.834 (1.085∼3.100) *
rs7664413
CC	177 (57.1%)	100 (60.2%)	1.00	1.00
CT	120 (38.7%)	58 (34.9%)	0.856 (0.575∼1.274)	1.122 (0.677∼1.862)
TT	13 (4.2%)	8 (4.8%)	1.089 (0.437∼2.717)	1.188 (0.335∼4.211)
CT+TT	133 (42.9%)	66 (39.8%)	0.878 (0.598∼1.289)	1.129 (0.692∼1.841)
rs2046463
AA	177 (57.1%)	100 (60.2%)	1.00	1.00
AG	120 (38.7%)	58 (34.9%)	0.856 (0.575∼1.274)	1.122 (0.677∼1.862)
GG	13 (4.2%)	8 (4.8%)	1.089 (0.437∼2.717)	1.188 (0.335∼4.211)
AG+GG	133 (42.9%)	66 (39.8%)	0.878 (0.598∼1.289)	1.129 (0.692∼1.841)

Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated by logistic regression models. Adjusted ORs (AORs) and their 95% CIs were estimated by multiple logistic regression models after controlling for age and gender.

*p<0.05, statistically significant.