Table 4. Distribution frequencies of vascular endothelial growth factor (VEGF)-C genotypes in 210 controls and 67 patients with urothelial cell carcinoma (UCC) who consumed tobacco.

Variable	Controls (N = 210) n (%)	Patients (N = 67) n (%)	OR (95% CI)	AOR (95% CI)
	Among tobacco consumers (n = 277)
rs3775194
GG	140 (66.7%)	49 (73.1%)	1.00	1.00
GC	68 (32.4%)	18 (26.9%)	0.756 (0.410∼1.396)	0.998 (0.391∼2.549)
CC	2 (0.9%)	0 (0%)	–	–
GC+CC	70 (33.3%)	18 (26.9%)	0.735 (0.399∼1.354)	0.966 (0.379∼2.462)
rs11947611
AA	93 (44.3%)	25 (37.3%)	1.00	1.00
AG	97 (46.2%)	32 (47.8%)	1.227 (0.677∼2.226)	1.216 (0.497∼2.973)
GG	20 (9.5%)	10 (14.9%)	1.860 (0.773∼4.476)	3.819 (0.694∼21.027)
AG+GG	117 (55.7%)	42 (62.7%)	1.335 (0.759∼2.350)	1.412 (0.595∼3.353)
rs1485766
CC	66 (31.4%)	21 (31.3%)	1.00	1.00
CA	105 (50.0%)	28 (41.8%)	0.838 (0.440∼1.596)	2.168 (0.771∼6.093)
AA	39 (18.6%)	18 (26.9%)	1.451 (0.690∼3.051)	3.219 (0.912∼15.587)
CA+AA	144 (68.6%)	46 (68.7%)	1.004 (0.555∼1.816)	2.671 (0.930∼6.929)
rs7664413
CC	132 (62.9%)	32 (47.8%)	1.00	1.00
CT	68 (32.4%)	31 (46.3%)	1.818 (1.059∼3.339) *	3.730 (1.384∼10.056) *
TT	10 (4.7%)	4 (5.9%)	1.650 (0.486∼5.601)	2.377 (0.227∼24.862)
CT+TT	78 (37.1%)	35 (52.2%)	1.851 (1.062∼3.225) *	3.595 (1.359∼9.512) *
rs2046463
AA	132 (62.9%)	32 (47.8%)	1.00	1.00
AG	68 (32.4%)	31 (46.3%)	1.818 (1.059∼3.339) *	3.730 (1.384∼10.056) *
GG	10 (4.7%)	4 (5.9%)	1.650 (0.486∼5.601)	2.377 (0.227∼24.862)
AG+GG	78 (37.1%)	35 (52.2%)	1.851 (1.062∼.225) *	3.595 (1.359∼9.512) *

Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated by logistic regression models. Adjusted ORs (AORs) and their 95% CIs were estimated by multiple logistic regression models after controlling for age and gender.

*p<0.05, statistically significant.