Table 5. Distribution frequencies of the clinical status and vascular endothelial growth factor (VEGF)-C rs7664413 genotype frequencies in urothelial cell carcinoma (UCC) patients with or without tobacco consumption.
| Among non-tobacco consumers (n = 166) | Among tobacco consumers (n = 67) | |||||||
| Variable | CC (N = 100) n (%) | CT+TT (N = 66) n (%) | OR (95% CI) | p value | CC (N = 32) n (%) | CT+TT (N = 35) n (%) | OR (95% CI) | p value |
| Stage | ||||||||
| Superficial tumor (pTa∼pT1) | 54 (54.0%) | 45 (68.2%) | 1.00 | 21 (65.6%) | 22 (62.9%) | 1.00 | ||
| Invasive tumor (pT2∼pT4) | 46 (46.0%) | 21 (31.8%) | 0.548 (0.286∼1.050) | 0.068 | 11 (34.4%) | 13 (37.1%) | 1.128 (0.415∼3.070) | 0.813 |
| Tumor T status | ||||||||
| T0 | 21 (21.0%) | 20 (30.3%) | 1.00 | 16 (50.0%) | 8 (22.9%) | 1.00 | ||
| T1∼T4 | 79 (79.0%) | 46 (69.7%) | 0.611 (0.300∼1.246) | 0.174 | 16 (50.0%) | 27 (77.1%) | 3.375 (1.181∼9.645) | 0.021* |
| Lymph node status | ||||||||
| N0 | 89 (89.0%) | 62 (93.9%) | 1.00 | 28 (87.5%) | 33 (94.3%) | 1.00 | ||
| N1+N2 | 11 (11.0%) | 4 (6.1%) | 0.522 (0.159∼1.715) | 0.277 | 4 (12.5%) | 2 (5.7%) | 0.424 (0.072∼2.492) | 0.331 |
| Metastasis | ||||||||
| M0 | 100 (100%) | 65 (98.5%) | 1.00 | 31 (96.9%) | 33 (94.3%) | 1.00 | ||
| M1 | 0 (0%) | 1 (1.5%) | – | 0.217 | 1 (3.1%) | 2 (5.7%) | 1.879 (0.162∼21.772) | 0.609 |
| Histopathologic grading | ||||||||
| Low grade | 10 (10.0%) | 13 (19.7%) | 1.00 | 7 (21.9%) | 6 (17.1%) | 1.00 | ||
| High grade | 90 (90.0%) | 53 (80.3%) | 0.453 (0.186∼1.105) | 0.077 | 25 (78.1%) | 29 (82.9%) | 1.353 (0.402∼4.559) | 0.625 |