Table 4.
Range of ALT and ALP by Injury Pattern
| Labs at Biopsy |
Zimmerman† |
|||
|---|---|---|---|---|
| Injury Pattern | ALT/ULN* (×) | ALP/ULN* (×) | ALT/ULN (×) | ALP/ULN (×) |
| Acute hepatitic | 12.8-27.4 | 1.0-2.9 | 10-100 | 1-3 |
| Chronic hepatitic | 3.4-9.5 | 0.9-2.3 | 3-50 | 1-3 |
| Acute cholestatic | 2.1-10.0 | 1.3-3.8 | 1-5 | 1-3 |
| Chronic cholestatic | 2.5-11.5 | 2.2-8.4 | 1-5 | 3-20 |
| Cholestatic hepatitic | 1.7-13.1 | 1.2-3.2 | 1-10 | >3 |
| Necrosis (zonal) | 6.4-46.7 | 0.9-1.7 | 10-1,000 | 1-3 |
*
Ranges represent 25th to 75th percentile of the laboratory data obtained at the time of liver biopsy, with ALT and ALP normalized to the local laboratory ULN.
Ranges adapted from Tables 4.25 and 4.26 on p. 103 of a previous work.9