Table 3.
New expanded classification system for canine cystinuria according to the novel metabolic and genetic findings (nd = not determined).
| Phenotype | Type I - A | Type II - A | Type II - B | Type III - | |
|---|---|---|---|---|---|
| Inheritance | Autosomal recessive | Autosomal dominant | Autosomal dominant | Sex limited | |
| Gene | SLC3A1 | SLC3A1 | SLC7A9 | Undetermined | |
| Sex | Males and Females | Males and Females | Males and Females | Intact Adult Males | |
| Androgen dependence | No | No | No | Yes | |
|
COLA
μmol/g creatinine (normal ≤ 500) |
homozygous | ≥ 8,000 | ≥ 8,000 | nd | ≤ 4,000 |
| heterozygous | ≤ 500 | ≥ 3,000 | ≥ 700 | ||
| Breeds |
Newfoundland
Landseer Labrador |
Australian Cattle Dog | Miniature Pinscher |
Mastiff &
Related Breeds Scottish Deerhound Irish Terrier |
|